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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH18A1
All Species:
43.03
Human Site:
Y668
Identified Species:
67.62
UniProt:
P54886
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54886
NP_001017423.1
795
87302
Y668
V
K
S
L
R
T
E
Y
G
D
L
E
L
C
I
Chimpanzee
Pan troglodytes
XP_001155890
796
87730
Y669
V
K
S
L
R
T
E
Y
G
D
L
E
L
C
I
Rhesus Macaque
Macaca mulatta
XP_001099359
795
87154
Y668
V
K
S
L
R
T
E
Y
G
D
L
E
L
C
I
Dog
Lupus familis
XP_534976
795
87233
Y668
V
K
S
L
R
T
E
Y
G
D
L
E
L
C
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z110
795
87278
Y668
V
K
S
L
R
T
E
Y
G
D
L
E
V
C
I
Rat
Rattus norvegicus
NP_001101994
795
87311
Y668
V
K
S
L
R
T
E
Y
G
D
L
E
V
C
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508419
607
66410
V489
D
L
E
C
C
I
E
V
V
D
S
V
Q
E
A
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086040
815
89190
Y688
V
R
S
L
R
T
E
Y
G
D
L
E
C
C
L
Zebra Danio
Brachydanio rerio
NP_001077015
782
85358
Y650
V
K
S
L
R
T
E
Y
G
D
L
E
C
C
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649375
776
84074
Y654
A
K
S
L
K
H
E
Y
G
A
L
E
C
C
I
Honey Bee
Apis mellifera
XP_396399
732
79216
Y608
A
K
S
M
K
T
E
Y
G
A
L
E
C
A
I
Nematode Worm
Caenorhab. elegans
P54889
800
86509
Y662
A
E
S
M
S
F
E
Y
G
S
L
E
C
T
L
Sea Urchin
Strong. purpuratus
XP_781524
752
81324
Y619
A
D
S
M
S
I
E
Y
G
G
L
E
C
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54888
726
78853
E608
A
C
T
V
E
I
V
E
D
V
Y
G
A
I
D
Baker's Yeast
Sacchar. cerevisiae
P54885
456
49722
F338
S
L
D
L
A
A
K
F
V
T
S
T
E
S
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.9
97.4
97.1
N.A.
95.3
95.2
N.A.
71.6
N.A.
84.4
82.1
N.A.
55.9
54.7
52.5
56.4
Protein Similarity:
100
94.9
98.2
98.6
N.A.
97.7
97.4
N.A.
74.9
N.A.
90.8
91.5
N.A.
70.8
69.5
69.5
73.3
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
13.3
N.A.
80
93.3
N.A.
66.6
60
40
40
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
N.A.
93.3
93.3
N.A.
73.3
73.3
60
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.1
38.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
0
0
0
7
7
0
0
0
14
0
0
7
14
14
% A
% Cys:
0
7
0
7
7
0
0
0
0
0
0
0
40
60
0
% C
% Asp:
7
7
7
0
0
0
0
0
7
60
0
0
0
0
7
% D
% Glu:
0
7
7
0
7
0
87
7
0
0
0
80
7
7
0
% E
% Phe:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
80
7
0
7
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
20
0
0
0
0
0
0
0
7
60
% I
% Lys:
0
60
0
0
14
0
7
0
0
0
0
0
0
0
0
% K
% Leu:
0
14
0
67
0
0
0
0
0
0
80
0
27
0
14
% L
% Met:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
7
0
0
54
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
0
80
0
14
0
0
0
0
7
14
0
0
7
0
% S
% Thr:
0
0
7
0
0
60
0
0
0
7
0
7
0
7
0
% T
% Val:
54
0
0
7
0
0
7
7
14
7
0
7
14
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
80
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _